When to consider a liver biopsy

Although a liver biopsy can confirm an existence of a fatty liver disease, for the majority of patients it is not required for NAFLD prognosis.

However, there are some specific purposes to a liver biopsy:

  • A biopsy can exclude other liver disorders
  • It can distinguish between simple fatty liver and acute fatty liver
  • Can provide information about the stage of hepatic fibrosis in non-alcoholic fatty liver
Liver Biopsy

Liver Biopsy

So when should you consider a liver biopsy?

There is no need to perform a liver biopsy on all non-alcoholic fatty liver patients. As for today, there are no specific rules on when a patient needs to take the biopsy or not.

However, a liver biopsy is sometimes considered if the patient is:

  • At the age of 45 years or older
  • Is diabetic and overweight (or obese)
  • Suffers from hypertension and hypertriglyceridaemia

Most liver experts would recommend trying to lower the ALT enzyme levels before performing a liver biopsy.

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2 Responses to “When to consider a liver biopsy”

  1. Adam Savage Says:

    “Most liver experts would recommend trying to lower the ALT enzyme levels before performing a liver biopsy”

    Would a biopsy be appropriate if:
    -Patient has been diagnosed with Fatty Liver
    -enzymes had spiked in the past but are now within normal range
    -Has had growing consistent aching on right side at the bottom of the rib cage for several weeks (appendix issues have been ruled out)

  2. Mark Bar-Gabel Says:

    Adam, its very conditional. In a case where a patient has been already diagnosed with fatty liver, and liver enzyme levels have been lowered, a liver biopsy isn’t recommended.

    Is this particular case, a liver biopsy might be considered to rule out other conditions the patient has.

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